Title:A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds
VOLUME: 13 ISSUE: 21
Author(s):Maria Jose Alves, Isabel C.F.R. Ferreira*, Joana Dias, Vania Teixeira, Anabela Martins and Manuela Pintado*
Affiliation:CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Escola Superior de Saúde, Instituto Politécnico de Bragança, Av. D. Afonso V, 5300-121 Bragança, Escola Superior de Saúde, Instituto Politécnico de Bragança, Av. D. Afonso V, 5300-121 Bragança, Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto
Keywords:Antifungal activity, antifungal proteins, basidiomycetes, grifolin.
Abstract:The present review reports the antifungal activity of mushroom extracts and isolated compounds including high
(e.g. peptides and proteins) and low (e.g. sesquiterpenes and other terpenes, steroids, organic acids, acylcyclopentenediones
and quinolines) molecular weight compounds. Most of the studies available on literature focused on screening of
antifungal activity of mushroom extracts, rather than of isolated compounds. Data indicate that mushroom extracts are
mainly tested against different Candida species, while mushroom compounds are mostly tested upon other fungi. Therefore,
the potential of these compounds might be more useful in food industry than in clinics. Oudemansiella canarii and
Agaricus bisporus methanolic extracts proved to be the most active mushroom extracts against Candida spp. Grifolin, isolated
from Albatrellus dispansus, seemed to be the most active compound against phytopathogenic fungi. Further studies
should be performed in order to better understand the mechanism of action of this and other antifungal compounds as well
as safety issues.
