Synthesis and Antiproliferative Activity of New Polyoxo 2-Benzyl-2,3- dihydrobenzofurans and Their Related Compounds

Author(s): Ping Qi, Jianhua Jiang, Huan Qi, Yinghua Jin, Qirong Shen, Yingliang Wu, Hongrui Song, Weige Zhang

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 9 , 2013

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A set of new polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds, including 2- benzylbenzofuran-3(2H)-ones and 2-benzylbenzofurans, were designed and synthesized. Their antiproliferative activities were evaluated against human gastric cancer (SGC-7901), human fibrosarcoma (HT-1080) and human oral epidermoid carcinoma (KB) cell lines in vitro. Preliminary results showed that some polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds had significant activity comparable with that of cisplatin.

Keywords: Antiproliferative activity, Synthesis, Aurone, 2-Benzyl-2, 3-dihydrobenzofuran, 2-Benzylbenzofuran-3(2H)-ones, 2-Benzylbenzofurans.

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Article Details

Year: 2013
Page: [886 - 894]
Pages: 9
DOI: 10.2174/15701808113109990011
Price: $65

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