Diabetes and hypertension frequently coexist and constitute the most notorious combination for the
pathogenesis of DR. Large clinical trials have clearly demonstrated that tight control of glycaemia and/or blood pressure
significantly reduces the incidence and progression of DR. The mechanism by which hypertension interacts with diabetes
to exacerbate the retinal disease is not completely understood. From experimental studies, increasing evidence
demonstrates that chronic inflammation and oxidative stress are involved. In the present review, we summarize data
obtained from our research along with those from other groups to better understand the role of hypertension in the
pathogenesis of DR. It is suggested that oxidative stress and inflammation may be common denominators of retinal
damage in the presence of hypertension in diabetic patients.
Keywords: Diabetes, DR, hypertension, inflammation, oxidative stress, renin-angiotensin system.
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