One-pot Synthesis of 2-Substituted Benzoxazoles Promoted by Copper Acetate Monohydrate

Author(s): Guo-Feng Chen, Hai-Dong Shen, Li-Yan Zhang, Hong-Yang Li, Rui-Jia Lan, Bao-Hua Chen, Ji-Tai Li, Qing-Hui Hu

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 3 , 2014

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Abstract:

An efficient synthesis of 2-substituted benzoxazoles via copper acetate monohydrate oxidative coupling of aldehydes with o-aminophenol is described. This synthetic strategy has some advantages as simple procedure, inexpensive and easily available catalyst, and facile isolation of the products in moderate to good yields.

Keywords: Benzoxazoles, aromatic aldehydes, o-aminophenol, copper acetate monohydrate, oxidative cyclization.

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2014
Page: [180 - 187]
Pages: 8
DOI: 10.2174/15701786113106660070
Price: $65

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