Physical and Chemical Stimuli-Responsive Drug Delivery Systems: Targeted Delivery and Main Routes of Administration

Author(s): Joana R. Lopes, Gory Santos, Pedro Barata, Rita Oliveira, Carla M. Lopes

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 41 , 2013

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In the area of drug delivery, novel tools and technological approaches have captured the attention of researchers in order to improve the performance of conventional therapeutics and patient compliance to pharmacological therapy. Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated and then modulated through some action or external input and facilitated by the energy supplied externally. The stimuli responsible to activate the drug release can be classified into three types according to their nature or the type of energy applied: physical (e.g. magnetic field, electric field, ultrasound, temperature and osmotic pressure); chemical (e.g. pH, ionic strength and glucose); and biological (enzymes and endogenous receptors). The present review gives an overview of the most significant physical and chemical stimuliresponsive DDS and elucidates about their current and relevant applications in controlled and targeted drug delivery attending different routes of administration.

Keywords: Stimuli-responsive DDS, Chemical stimuli, Physical stimuli, Biological stimuli, Controlled drug release, Smart polymers, Targeted DDS, Specific delivery.

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Article Details

Year: 2013
Published on: 19 December, 2013
Page: [7169 - 7184]
Pages: 16
DOI: 10.2174/13816128113199990698
Price: $65

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PDF: 57