Immune Senescence and Vaccination in the Elderly

Author(s): Pierre Olivier Lang, Sheila Govind, Annemieke ten Bokum, Natalie Kenny, Emmanuel Matas, David Pitts, Richard Aspinall

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 20 , 2013

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Vaccines are powerful public health tools that have been of tremendous benefit in protecting vulnerable populations worldwide from many pathogens. However, vaccine- preventable diseases still remain a considerable burden and this is particularly true among aging and aged populations in industrialized countries. The predicted demographic shift in the population landscape towards an ever-increasing aging population and the evidence suggesting that older individuals mount less-than optimal immune response to vaccination have raised the question of improving vaccine responses in older individuals. This review presents recent progress in the understanding at the cellular and molecular levels of age related immune decline and strategies to translate current knowledge into the development of immunization strategies to promote healthy aging, keeping older members of our society autonomous and independent.

Keywords: Healthy aging, immunosenescence, older adults, vaccination, vaccine design, vaccine development, vaccine effectiveness.

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Article Details

Year: 2013
Published on: 28 October, 2013
Page: [2541 - 2550]
Pages: 10
DOI: 10.2174/15680266113136660181
Price: $65

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