Title:L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems
VOLUME: 1 ISSUE: 1
Author(s):Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar
Affiliation:Department of Chemistry, University of Rajasthan, Jaipur, 302004, India.
Keywords:2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines,
Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis,
L-proline, pyranoquinolines.
Abstract:Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed
four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and
carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol
attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental
safety.
