Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative
diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of
major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some
light on the future direction of drug discovery against prion and other neurodegenerative diseases.
Keywords: Quinacrine, antiprion, prion protein, drug discovery, indole, prion diseases, pyridine dicarbonitrile, thiazole.
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