Logical Design of Medical Chaperone for Prion Diseases

Author(s): Kazuo Kuwata

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 19 , 2013

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A strategy of logical drug design (LDD) and its application to prion diseases are reviewed. LDD is primarily based on the localizability of a hot spot which initiates structural instability in the target protein. It is also based on the regulability of the hot spot by small compounds, their designabilty by a computer, their organic synthesizability and the specificity of their functions once administered to the biological organisms. Unification of localizability, regulability, producibility and specificity is the central theme of LDD. Theoretical foundation of LDD based on quantum theories is initially outlined. The localizability using nuclear magnetic resonance (NMR), the regulability by a medical chaperone, the synthesizability, and the functional specificity accomplished thus far, are then described.

Keywords: Logical drug design, quantum chemistry, prion, hot spot, medical chaperone.

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Article Details

Year: 2013
Page: [2432 - 2440]
Pages: 9
DOI: 10.2174/15680266113136660171
Price: $65

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PDF: 11