NMR Analysis of Potentially Neurotoxic Annonaceous Fruits

Title:NMR Analysis of Potentially Neurotoxic Annonaceous Fruits

Volume: 3 Issue: 3

Author(s): Rensheng Rensheng Luo, José Guilherme S. Maia, Maria Rosa de Moraes, Helena T. Godoy, Armando A.U. Sabaa-Srur, Kevin Tran, Kristy M. Richards, Douglas M. Monroe, Ralph H. Vocque and Robert E. Smith

Affiliation:

Keywords: Parkinson's, annona muricata, A. squamosa x A. cherimola, rollinia mucosa.

Abstract: Graviola (Annona muricata), atemoya (A. squamosa x A. cherimola), ata (A. squamosa) and biribá (Rollinia mucosa) lyophilized fruit pulps and atemoya seeds were extracted with methanol at 100 °C and 10.3 MPascal pressure using an Accelerated Solvent Extractor (ASE) and analyzed by NMR to see if they have the known toxicophores (an α,β-unsaturated γ-lactone and substituted tetrahydrofuran ring) that are in the neurotoxins annonacin and squamocin. The spectra of extracts from graviola, ata and biribá pulp and atemoya seeds showed the possible presence of relatively large amounts of these toxicophores. There was much less in the extracts of atemoya pulp. Thus, NMR analysis can be used to screen these fruits for the possible presence of the known toxicophores. Moreover, the methanol-soluble material in all four fruits showed the presence of glycosides as the major components.

Cite this article as:

Rensheng Luo Rensheng, S. Maia Guilherme José, de Moraes Rosa Maria, Godoy T. Helena, Sabaa-Srur A.U. Armando, Tran Kevin, Richards M. Kristy, Monroe M. Douglas, Vocque H. Ralph and Smith E. Robert, NMR Analysis of Potentially Neurotoxic Annonaceous Fruits, The Natural Products Journal 2013; 3 (3) . https://dx.doi.org/10.2174/2210315511303030011