Microglia and Neuropathic Pain

Author(s): Håkan Aldskogius, Elena N. Kozlova

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 12 , Issue 6 , 2013


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Abstract:

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.

Keywords: Nerve injury, spinal cord injury, neuropathy, cytokine, chemokine, purine receptor, plasticity.

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Article Details

VOLUME: 12
ISSUE: 6
Year: 2013
Published on: 18 September, 2013
Page: [768 - 772]
Pages: 5
DOI: 10.2174/18715273113126660168
Price: $65

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