Curcumin, a natural diaryl heptanoid continues to be used as an alternative medicinal agent in many parts of
South East Asia for treatment of many ailments. It can be usually obtained from substituted aryl aldehydes and
acetylacetone and this route enables synthesis of a diverse set of curcumin analogues. Numerous analogues have been
synthesized and tested by several researchers to investigate their activity against known biological targets and to improve
upon the pharmacological and ADME profile by modifying substitutions on aromatic rings, β-diketone moiety and two
flanking double bonds conjugated to the β-diketone moiety. Successful synthesis of such derivatives with modifications
has resulted in the development of potential anticancer candidates that target various stages in cancer cell growth and
development. Based on the evidences in modifications of these three functional elements, we have attempted to
summarize the structure activity relationship of molecules which can be further utilized by researchers in medicinal
chemistry in exploring the structure of curcumin.
Keywords: Curcumin, Anticancer activity of curcumin, SAR, potent derivatives of curcumin.
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