Abstract
Creation of effective antidepressant drugs is the key problem of the modern neuropharmacology. Here, the effect of acute administration of a new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6- amine hydrochloride (TC-2153) (10 and 20 mg/kg), on depressive-like behavior in the forced swim test (FST), anxietylike behavior and locomotion in the open field (OFT) and in the elevated plus-maze (PMT) tests was compared with those of classic antidepressant drugs, fluoxetine (20 mg/kg) and imipramine (20 mg/kg). Experiments were performed on adult male mice of AKR.CBA-D13Mit76 recombinant strain. TC-2153 at the doses of 10 or 20 mg/kg as well as fluoxetine and imipramine significantly decreased immobility time in the FST. Both doses of TC-2153 did not alter mouse behavior in the OFT. At the same time, imipramine significantly reduced the distance travelled and the number of rearing bouts, while fluoxetine decreased the number of rearing bouts in the OFT. All drugs produced no effect on the time spent in the center of the OFT and in the open arms in the PMT. These results suggest that TC-2153 is a promising psychotropic drug with the antidepressant-like activity similar to imipramine or fluoxetine, but lacking any visible negative side effect (reduction of locomotion or exploratory behavior).
Keywords: Antidepressants, Benzopentathiepin, Fluoxetine, Iimipramine, Forced swim, Open field, Plus-maze, Mice.
Letters in Drug Design & Discovery
Title:Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin- 6-amine hydrochloride (TC-2153): Comparison with Classical Antidepressants
Volume: 11 Issue: 2
Author(s): Alexander V. Kulikov, Maria A. Tikhonova, Elizabeth A. Kulikova, Konstantin P. Volcho, Tatyana M. Khomenko, Nariman F. Salakhutdinov and Nina K. Popova
Affiliation:
Keywords: Antidepressants, Benzopentathiepin, Fluoxetine, Iimipramine, Forced swim, Open field, Plus-maze, Mice.
Abstract: Creation of effective antidepressant drugs is the key problem of the modern neuropharmacology. Here, the effect of acute administration of a new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6- amine hydrochloride (TC-2153) (10 and 20 mg/kg), on depressive-like behavior in the forced swim test (FST), anxietylike behavior and locomotion in the open field (OFT) and in the elevated plus-maze (PMT) tests was compared with those of classic antidepressant drugs, fluoxetine (20 mg/kg) and imipramine (20 mg/kg). Experiments were performed on adult male mice of AKR.CBA-D13Mit76 recombinant strain. TC-2153 at the doses of 10 or 20 mg/kg as well as fluoxetine and imipramine significantly decreased immobility time in the FST. Both doses of TC-2153 did not alter mouse behavior in the OFT. At the same time, imipramine significantly reduced the distance travelled and the number of rearing bouts, while fluoxetine decreased the number of rearing bouts in the OFT. All drugs produced no effect on the time spent in the center of the OFT and in the open arms in the PMT. These results suggest that TC-2153 is a promising psychotropic drug with the antidepressant-like activity similar to imipramine or fluoxetine, but lacking any visible negative side effect (reduction of locomotion or exploratory behavior).
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Cite this article as:
V. Kulikov Alexander, A. Tikhonova Maria, A. Kulikova Elizabeth, P. Volcho Konstantin, M. Khomenko Tatyana, F. Salakhutdinov Nariman and K. Popova Nina, Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin- 6-amine hydrochloride (TC-2153): Comparison with Classical Antidepressants, Letters in Drug Design & Discovery 2014; 11 (2) . https://dx.doi.org/10.2174/15701808113106660079
DOI https://dx.doi.org/10.2174/15701808113106660079 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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