Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans

Author(s): Konstantinos Daniilides, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Pinelopi Samara, Ourania Tsitsilonis

Journal Name: Medicinal Chemistry

Volume 10 , Issue 6 , 2014

Become EABM
Become Reviewer

Graphical Abstract:


A number of new aminosubstituted benzofuran analogues have been prepared and their cytotoxic/cytostatic activity was investigated against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa). Certain compounds showed noticeable tumor cell growth inhibition, indicative of possible structure-activity relationships.

Keywords: Benzofurans, Cytotoxicity, Heterocycles, Sonogashira cross-coupling, Wadsworth-Emmons reaction.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Page: [619 - 627]
Pages: 9
DOI: 10.2174/15734064113096660049
Price: $65

Article Metrics

PDF: 27