It is new approach to combine one or multiple drugs onto the same drug-delivery nanocarrier in accurately
controllable manner, by covalently preconjugating one or multiple therapeutic agents by covalent bond to form drug
conjugates. It provides the advantages of nano size system with the targeted delivery of drug with great precision. The
conjugation system allows the modification in the metabolic path way in the blood stream and can target the delivery to
the heart, liver or brain. The cleavable covalent bond allows the therapeutic activity of the individual drugs to be resumed
after the drug conjugates are delivered into the target site and get separated from the carriers. The characters of drug
conjugated system are (a) a covalent bond between drug and carrier moiety, (b) in vitro cleavage of the bond, (c) optimum
release of drug at site of action to ensure effectiveness, (d) no alteration in drug action. As a proof of the concept,
synthesis and characterization of stearic acid/oleic acid- diminazene conjugates nanoparticles are demonstrated. It is
shown that after conjugation with lipid and/or polymer and synthesized to nanoparticles there is significant improvement
in cyctotoxicity and targeted controlled delivery of drug than the free drug.
Keywords: Carriers, Lipid-drug conjugation, Metabolism, Modification, Nanomedicine, Polymer-drug conjugation.
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