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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Small Molecule PET-Radiopharmaceuticals

Author(s): Philip H. Elsinga and Rudi A.J.O. Dierckx

Volume 20, Issue 14, 2014

Page: [2268 - 2274] Pages: 7

DOI: 10.2174/13816128113196660661

Price: $65

Abstract

This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in 11C and 18F-radiochemistry are summarized. In addition an update of some new developments in regulatory aspects is supplied.

Keywords: PET, small molecules, radiochemistry, preclinical evaluation, carbon-11, fluorine-18.


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