Application of Monoterpenoids and their Derivatives Against CNS Disorders
Pp. 334-380 (47)
Alla V. Pavlova, Konstantin P. Volcho and Tatyana G. Tolstikova
Monoterpenoids and their derivatives play an important role in the creation of
new bioactive substances including drugs. Many of these compounds possess
substantial CNS activities such as antinociceptive, neuroprotective, anticonvulsant. In
the past decades, interest in investigating the possibility of using monoterpenoids for the
development of new drugs has increased significantly due to improvement of both
chemical methods of modification of natural compounds, and a substantial deficit of
breakthrough research to create drugs to treat diseases associated with central nervous
system. The review covers the literature on monoterpenoids and their derivatives exhibit
various types of CNS activities published up to early 2012.
Essential oils, monoterpenoids, analgesic activity, anticonvulsant
activity, neuroprotective activity, inhibition of acetylcholinesterase activity, anti-
Alzheimer’s disease activity, antiparkinsonian activity, anxiolytic-like effect,
Novosibirsk institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russia.