Title:Pharmacokinetics of CNT-based Drug Delivery Systems
VOLUME: 14 ISSUE: 8
Author(s):Rui Ye, Sheng Wang, Jing Wang, Zhiqiang Luo, Qiang Peng, Xiaoxiao Cai and Yunfeng Lin
Affiliation:State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14., 3rd Sec, Ren Min Nan Road, Chengdu 610041, P.R. China.
Keywords:Absorption, CNT, distribution, drug release, excretion, intracellular internalization, metabolism, tumor targeting.
Abstract:Carbon nanotubes (CNT) are allotropes of carbon with a cylindrical nanostructure. They have recently aroused great interests
as drug carriers, but their pharmacokinetic profiles which determine their potentials in clinical application are yet to be fully understood.
Therefore, this overview attempts to outline the processes of absorption, distribution, metabolism and excretion (ADME) that govern the
pharmacokinetics of CNT. In addition, the molecular mechanisms of intracellular internalization and drug release are also discussed.
