Advancements in the design and synthesis of polymer-based nanoassemblies and nanoparticles, combined with achievements
in nanotechnology and medicine, have resulted in remarkable applications of polymer nanosystems in the areas of nanomedicine and
pharmaceutical sciences. However, a complete understanding of the absorption, distribution, metabolism, and elimination (ADME) processes
of such polymer nanosystems in living systems has not been achieved. The influences of the pharmacokinetic parameters of polymer
nanomaterials on the ADME processes are reviewed in this article, with discussions of the absorption and transportation of polymer
nanoparticles across biological barriers, the factors affecting the bodily distribution of polymer nanocarriers, the transformation of polymer
nanomaterials in vivo, the elimination pathway of polymer nanoparticles from biological systems, and perspectives of future pharmacokinetics
and safety investigations of polymer-based nanoassemblies. A full and better understanding of the pharmacokinetic parameters
of polymer-based nanomaterials is of vital importance in developing polymer nanosystems with optimal pharmacokinetics and biological
safety for applications in nanomedicine and the pharmaceutical industry.
Keywords: Absorption, distribution, elimination, metabolism, nanomedicine, pharmacokinetics, polymer nanoparticles.
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Published on: 31 August, 2013
Page: [832 - 839]