The aim of the work is to modify the solubility and bioavailability of Losartan potassium, by employing noneffervescent
floating drug delivery (tablet dosage forms). Non-effervescent systems are a type of floating drug delivery
systems, that have been used to boost the gastric residence and the floatation time in the gastro intestinal tract. The study
included formulation of floating tablets using polymers like Chitosan and Karaya gum as matrix forming agents. Accurel®
MP 1000 was used as floating agent. The tablets were prepared by direct compression technique. FTIR, DSC studies
conformed that there was no incompatibility between the polymer and the drug. Tablet preformulation parameters were
within the Pharmacopoeial limit. Tablet showed zero lag time, contisnuance of buoyancy for >12 h. The tablet showed
good in vitro release. Drug release was through swelling and abided by the gellation mechanism. In vivo X-ray studies
depicted that tablets continued to float in the GIT for 12 h. Accelerated stability showed that, tablets were stable for over 6
month. Thus the prepared non-effervescent floating tablet of Losartan potassium can be used for the treatment of
hypertension for more than 12 h with single dose administration.
Keywords: Accurel® MP 1000, Chitosan, Losartan potassium, Non-effervescent floating tablets, X- ray studies.
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