The present investigation describes development and optimization of pioglitazone-loaded jackfruit seed starch
(JFSS)-alginate beads by ionotropic-gelation using 32 factorial design. The effect of polymer-blend ratio and CaCl2
concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 hours (R10h, %) was
optimized. The DEE (%) of these beads were 64.80 ± 1.92 to 94.07 ± 3.82 % with sustained in vitro drug release of
64.±1.83 to 92.66 ± 4.54 % over 10 hours. The in vitro drug release from these beads followed controlled-release
pattern with super case-II transport. Particle size range of these beads was 0.77 ± 0.04 to 1.24 ± 0.09 mm. The beads were
also characterized by SEM and FTIR. The swelling of these beads was influenced by pH of the test medium. The
optimized pioglitazone-loaded JFSS-alginate beads showed significant hypoglycemic effect in alloxan-induced diabetic
rats over prolonged period after oral administration.
Keywords: Jackfruit seed starch, Alginate, Drug release, Controlled delivery, Pioglitazone, Factorial design.
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Published on: 31 August, 2013
Page: [608 - 619]