Effect of Processing Variables on Characterization of Ofloxacin Loaded Lipospheres Prepared by Melt Dispersion Technique

Author(s): Satheesh Babu Natarajan, Prabakaran Lakshmanan

Journal Name: Current Drug Delivery

Volume 10 , Issue 5 , 2013


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Abstract:

A melt dispersion technique was employed to prepare ofloxacin lipospheres, by using cetyl alcohol (polar lipid). Effects of various process parameters such as selection of surfactants (gelatin, Tween 40 and poly vinyl alcohol) and selection of stirring speed were studied. Lipospheres were evaluated for morphology, drug entrapment and in vitro drug release profiles. The optimized liposphere batch was selected and formulated as tablets and evaluated the in vitro drug release profile. These studies showed that ofloxacin loaded lipospheres were able to control the drug release for a period of 16h.

Keywords: Lipospheres, ofloxacin, melt dispersion, cetyl alcohol, gelatin, entrapment efficiency, drug release.

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2013
Published on: 31 August, 2013
Page: [517 - 526]
Pages: 10
DOI: 10.2174/1567201811310050003
Price: $65

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