Studies on Anticancer Activities of Lactoferrin and Lactoferricin

Author(s): Cui Ming Yin, Jack Ho Wong, Jiang Xia, Tzi Bun Ng

Journal Name: Current Protein & Peptide Science

Volume 14 , Issue 6 , 2013


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Abstract:

This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.

Keywords: Application, cancer, delta lactoferrin, lactoferrin, lactoferricin, mechanism, talactoferrin, drug delivery.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2013
Published on: 31 August, 2013
Page: [492 - 503]
Pages: 12
DOI: 10.2174/13892037113149990066
Price: $65

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