A series of novel derivatives of 1,3-oxazolidin-2-one 12a-12n has been synthesized starting from 4-nitro-(L)-
phenylalanine by involving five-step reaction sequence. All the compounds were screened for their in vitro antibacterial
activity against four pathogenic bacterial strains namely, Staphylococcus aureus, Bacillus subtilis (Gram-positive), Escherichia
coli, Pseudomonas aeruginosa (Gram-negative) and in vitro antifungal activity against two pathogenic fungal
strains namely, Candida albicans and Saccharomyces cerevisiae. All the synthesized compounds showed activity against
Gram-positive bacteria. Compounds 12c and 12l exhibited maximum antibacterial activity against Gram-positive bacteria.
However, against Gram-negative bacteria only five of screened compounds were found to be active. Compounds 12c and
12i displayed best antifungal activity against the tested fungi. Docking studies were carried out in order to gain insight
into the mechanism of action and the binding mode of these compounds. These studies were in agreement with the biological
Keywords: 1, 3-Oxazolidin-2-one, Azomethine, Antibacterial activity, Antifungal activity, Docking study.
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Published on: 31 August, 2013
Page: [2062 - 2075]