Title:Recent Advances in the Development of Antiviral Agents Using Computer-aided Structure Based Approaches
VOLUME: 20 ISSUE: 21
Author(s):Vikash Kumar, Sharat Chandra and Mohammad Imran Siddiqi
Affiliation:Molecular & Structural Biology Division CSIR-Central Drug Research Institute, Lucknow, India.
Keywords:Viral diseases, CADD, molecular docking, virtual screening.
Abstract:Viral diseases have been affecting the human race since ancient times. Currently, a long list of diseases caused by the viruses
is available and extensive research in this area has resulted in understanding the finest details of the molecular mechanism of pathogenesis
caused by these pathogens. Side by side, efforts have been made towards the search and design of antiviral agents that could interfere
with viral pathogenesis. As a result of these efforts a number of effective antiviral agents have been developed and are available in the
market. However, the high cost and lengthy protocol of the drug discovery process are some of the major limiting factors in the development
of new and more effective antiviral agents. Considering the above fact, presently the research community is trying to integrate short
and cost effective techniques in the modern drug discovery process for the identification and design of novel antiviral agents. Computeraided
drug design (CADD), which comprises of various techniques like molecular docking, virtual screening, three dimensional quantitative
structure activity relationship (3D-QSAR) studies and many more, has the capability to speed up the antiviral drug development
process. Successful design of antiviral drugs like Relenza, Saquinavir and Tamiflu have validated application of these techniques and
holds a bright future in drug discovery protocol. This review explores the role of CADD in antiviral drug development and highlights the
recent advances in antiviral drug research using computer-aided structure based approaches.
