Synthesis and Evaluation of Antioxidant-S-(+)-Ibuprofen Hybrids as Gastro Sparing NSAIDs

Author(s): Senthil Chandiran, Sandeep Vyas, Neetika Sharma, Manu Sharma

Journal Name: Medicinal Chemistry

Volume 9 , Issue 7 , 2013

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Ibuprofen is one of the most popular NSAIDs for the last three decades but also known for its gastrointestinal side effects similar to other NSAIDs. To overcome this problem, we have designed and synthesized ibuprofen - antioxidant (thymol, guaiacol, eugenol, and menthol) hybrids (6-13) with and without spacer as gastro sparing agents. The hybrids have been found to be chemically stable, biolabile and exhibited retention of anti-inflammatory and analgesic activity with significant reduced ulcerogenicity as compared to the ibuprofen and ibuprofen + antioxidant physical mixture. The absence of ulcerogenicity may be attributed to antioxidants and improved physicochemical properties of these hybrid molecules.

Keywords: Ibuprofen, Antioxidants, Ulcerogenicity, Chemical stability.

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Article Details

Year: 2013
Page: [1006 - 1016]
Pages: 11
DOI: 10.2174/1573406411309070015
Price: $65

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PDF: 18