Abstract
Metabolomics represents the global profiling of metabolites in a given biological system. It has been used to facilitate pharmaceutical discovery and development for over a decade. Advances in instrumentation have positioned capillary electrophoresis–mass spectrometry (CE-MS) as an important platform for both targeted and non-targeted metabolomics. In this mini-review covering the last five years, we focus on the latest development of CE-MS based metabolomics in (a) identification and validation of novel valuable therapeutic targets, (b) evaluation of drug efficacy, and (c) monitoring of drug unanticipated adverse effects. Some of the current issues and future directions of CE-MS metabolomics are also discussed in the end.
Keywords: Biomarkers, CE-MS, drug discovery and development, drug efficacy, drug toxicity metabolomics.
Current Drug Metabolism
Title:Capillary Electrophoresis–Mass Spectrometry in Metabolomics: The Potential for Driving Drug Discovery and Development
Volume: 14 Issue: 7
Author(s): Xu Wang, Kefeng Li, Erwin Adams and Ann Van Schepdael
Affiliation:
Keywords: Biomarkers, CE-MS, drug discovery and development, drug efficacy, drug toxicity metabolomics.
Abstract: Metabolomics represents the global profiling of metabolites in a given biological system. It has been used to facilitate pharmaceutical discovery and development for over a decade. Advances in instrumentation have positioned capillary electrophoresis–mass spectrometry (CE-MS) as an important platform for both targeted and non-targeted metabolomics. In this mini-review covering the last five years, we focus on the latest development of CE-MS based metabolomics in (a) identification and validation of novel valuable therapeutic targets, (b) evaluation of drug efficacy, and (c) monitoring of drug unanticipated adverse effects. Some of the current issues and future directions of CE-MS metabolomics are also discussed in the end.
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Cite this article as:
Wang Xu, Li Kefeng, Adams Erwin and Schepdael Van Ann, Capillary Electrophoresis–Mass Spectrometry in Metabolomics: The Potential for Driving Drug Discovery and Development, Current Drug Metabolism 2013; 14 (7) . https://dx.doi.org/10.2174/13892002113149990101
DOI https://dx.doi.org/10.2174/13892002113149990101 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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