Gastroenterological Complications of Anderson-Fabry Disease

Author(s): Piotr Buda, Janusz Ksiazyk, Anna Tylki-Szymaska

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 33 , 2013

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Fabry disease is a multisystemic X-linked lysosomal storage disorder, caused by the partial or complete deficiency of alphagalactosidase A activity. The storage of glycosphingolipids in the vascular endothelium and in various tissues can lead to a broad spectrum of clinical manifestations. Renal failure, cardiovascular disease, and strokes are the main causes of morbidity and mortality. Gastrointestinal symptoms, although common, are often under-reported in the literature. This review covers the gastroenterological aspects of Fabry disease.

Keywords: Fabry disease, diarrhoea, abdominal pain, gastrointestinal dysmotility, colitis.

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Article Details

Year: 2013
Page: [6009 - 6013]
Pages: 5
DOI: 10.2174/13816128113199990347
Price: $65

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PDF: 30