Abstract
Serpins in the mammalian body are highly potent serine protease inhibitors which modulate both thrombotic and thrombolytic pathway activation, with direct and indirect crosstalk with immune and inflammatory pathways. In this review, we discuss mammalian and viral serpins as regulators of coagulation and inflammation. We focus first on the thrombotic and thrombolytic serine proteases and known interactions between these protease cascades and elements of the innate immune response. Serpin-mediated regulation of the thrombotic pathway is then discussed, with emphasis on those serpins that have been evaluated as potential new drugs. Finally the potential of viral serpins that target the coagulation and thrombolytic cascades as potential therapeutics for anti-inflammatory properties is discussed from basic molecular activity to studies in animal models. The studies discussed range from thrombosis and hemorrhage to vascular disease and transplant rejection and finally to sepsis and clinical studies in humans. In conclusion, these unique proteins, the serpin family, now have demonstrated therapeutic potential for a wide variety of inflammatory diseases in both animal and human studies and represent a new approach for drug development.
Keywords: Serpin, protease, thrombosis, thrombolysis, vascular, inflammation.
Cardiovascular & Hematological Disorders-Drug Targets
Title:The Serpin Solution; Targeting Thrombotic and Thrombolytic Serine Proteases in Inflammation
Volume: 13 Issue: 2
Author(s): Hao Chen, Jennifer A. Davids, Donghang Zheng, Marsha Bryant, Ilze Bot, Theo J.C. van Berckel, Erik Biessen, Carl Pepine, Kate Ryman, Ann Progulski-Fox, Lakshmyya Kesavalu, Richard Moyer, Grant McFadden and Alexandra Lucas
Affiliation:
Keywords: Serpin, protease, thrombosis, thrombolysis, vascular, inflammation.
Abstract: Serpins in the mammalian body are highly potent serine protease inhibitors which modulate both thrombotic and thrombolytic pathway activation, with direct and indirect crosstalk with immune and inflammatory pathways. In this review, we discuss mammalian and viral serpins as regulators of coagulation and inflammation. We focus first on the thrombotic and thrombolytic serine proteases and known interactions between these protease cascades and elements of the innate immune response. Serpin-mediated regulation of the thrombotic pathway is then discussed, with emphasis on those serpins that have been evaluated as potential new drugs. Finally the potential of viral serpins that target the coagulation and thrombolytic cascades as potential therapeutics for anti-inflammatory properties is discussed from basic molecular activity to studies in animal models. The studies discussed range from thrombosis and hemorrhage to vascular disease and transplant rejection and finally to sepsis and clinical studies in humans. In conclusion, these unique proteins, the serpin family, now have demonstrated therapeutic potential for a wide variety of inflammatory diseases in both animal and human studies and represent a new approach for drug development.
Export Options
About this article
Cite this article as:
Chen Hao, Davids A. Jennifer, Zheng Donghang, Bryant Marsha, Bot Ilze, Berckel J.C. van Theo, Biessen Erik, Pepine Carl, Ryman Kate, Progulski-Fox Ann, Kesavalu Lakshmyya, Moyer Richard, McFadden Grant and Lucas Alexandra, The Serpin Solution; Targeting Thrombotic and Thrombolytic Serine Proteases in Inflammation, Cardiovascular & Hematological Disorders-Drug Targets 2013; 13 (2) . https://dx.doi.org/10.2174/1871529X11313020003
DOI https://dx.doi.org/10.2174/1871529X11313020003 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial [Hot Topic: Anti-Platelet Therapy (Guest Editor: Susan S. Smyth)]
Current Drug Targets Mild Cognitive Impairment: At the Crossroad of Neurodegeneration and Vascular Dysfunction
Current Alzheimer Research Heme Oxygenase -1 Gene Therapy: Recent Advances and Therapeutic Applications
Current Gene Therapy Aldosterone and the Pathogenesis of Hypertension
Current Hypertension Reviews Non-Invasive Assessment of Atherosclerosis Risk
Current Drug Targets - Cardiovascular & Hematological Disorders Urinary Incontinence in Sport Women: from Risk Factors to Treatment – A Review
Current Women`s Health Reviews DNA-Damaging Anticancer Drugs – A Perspective for DNA Repair- Oriented Therapy
Current Medicinal Chemistry Antiphospholipid Syndrome as a Neurological Disease
Current Rheumatology Reviews Reversal of Diabetes and Metabolic Disorders After Bariatric Surgery
Current Nutrition & Food Science Novel Inflammatory Biomarkers in Coronary Artery Disease: Potential Therapeutic Approaches
Current Medicinal Chemistry The Fetal Cardiac Function
Current Cardiology Reviews Biomedical Imaging in Implantable Drug Delivery Systems
Current Drug Targets Stroke as a Consequence of Sleep Apnea: Epidemiology, Pathophysiology and Treatment Strategies
Current Respiratory Medicine Reviews Pleiotropic Effects of Omega-3 Fatty Acids
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Peripheral Arterial Disease - The Forgotten Risk Factor
Vascular Disease Prevention (Discontinued) Autologous Circulating Progenitor Cells Transplanted with Hybrid Scaffold Accelerate Diabetic Wound Healing in Rabbit Model
Current Tissue Engineering (Discontinued) Obesity and Arterial Compliance Alterations
Current Vascular Pharmacology A Review of the Relationships Between Endogenous Sex Steroids and Incident Ischemic Stroke and Coronary Heart Disease Events
Current Cardiology Reviews Hereditary Haemorrhagic Telangiectasia: A Rare Disease As A Model for the Study of Human Atherosclerosis
Current Pharmaceutical Design Virtual Screening Against Obesity
Current Medicinal Chemistry