Abstract
We report recent postmortem findings from the Magdeburg Brain Bank related to the evaluation of impaired activity of neuronal networks relevant for depression. Chronic changes in ribosomal DNA transcriptional activity have been revealed by the quantitative evaluation of silver-stained nucleolar organising regions (AgNORs). Abnormalities in AgNOR parameters have been found in neurons of the prefrontal limbic regions, the amygdala, the external globus pallidus, and the serotonergic dorsal raphe nucleus (DRN). The impact of the processes leading to suicide has been clearly accentuated in opposition to the weak influence of unipolar-bipolar dichotomy, which was only revealed in one area (the anterior cingulate cortex). The impact of suicide was most pronounced in the DRN. Our AgNOR studies show that the influence of psychotropic medication (antidepressants and typical neuroleptics, among others) is limited in the prevention of abnormal neuronal activity specific for suicide.
Keywords: Depression, suicide, unipolar-bipolar dichotomy, postmortem, AgNOR staining.
CNS & Neurological Disorders - Drug Targets
Title:Postmortem-Assessed Impairment of Neuronal Activity in Depression: The Dominant Impact of Suicide
Volume: 12 Issue: 7
Author(s): Tomasz Gos, Johann Steiner, Zbigniew Jankowski and Bernhard Bogerts
Affiliation:
Keywords: Depression, suicide, unipolar-bipolar dichotomy, postmortem, AgNOR staining.
Abstract: We report recent postmortem findings from the Magdeburg Brain Bank related to the evaluation of impaired activity of neuronal networks relevant for depression. Chronic changes in ribosomal DNA transcriptional activity have been revealed by the quantitative evaluation of silver-stained nucleolar organising regions (AgNORs). Abnormalities in AgNOR parameters have been found in neurons of the prefrontal limbic regions, the amygdala, the external globus pallidus, and the serotonergic dorsal raphe nucleus (DRN). The impact of the processes leading to suicide has been clearly accentuated in opposition to the weak influence of unipolar-bipolar dichotomy, which was only revealed in one area (the anterior cingulate cortex). The impact of suicide was most pronounced in the DRN. Our AgNOR studies show that the influence of psychotropic medication (antidepressants and typical neuroleptics, among others) is limited in the prevention of abnormal neuronal activity specific for suicide.
Export Options
About this article
Cite this article as:
Gos Tomasz, Steiner Johann, Jankowski Zbigniew and Bogerts Bernhard, Postmortem-Assessed Impairment of Neuronal Activity in Depression: The Dominant Impact of Suicide, CNS & Neurological Disorders - Drug Targets 2013; 12 (7) . https://dx.doi.org/10.2174/18715273113129990094
DOI https://dx.doi.org/10.2174/18715273113129990094 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions
Current Drug Targets Targeting the PI3K/AKT/mTOR Signaling Pathway in Medulloblastoma
Current Molecular Medicine Successful Structure-Based Design of Recent p38 MAP Kinase Inhibitors
Current Topics in Medicinal Chemistry The Quest to Repair the Damaged Spinal Cord
Recent Patents on CNS Drug Discovery (Discontinued) The Development of PDGF Receptor Inhibitors for the Treatment of Glioma: A Review
Letters in Drug Design & Discovery Carbonic Anhydrases An Overview
Current Pharmaceutical Design Glycan Phosphorylases in Multi-Enzyme Synthetic Processes
Protein & Peptide Letters A Common Pathway for All Autoimmune Diseases? The Unholy Alliance of Environment, Cell Death and Nucleic Acids
Current Immunology Reviews (Discontinued) Proline-Directed Protein Kinase FA as a Potential Target for Diagnosis and Therapy of Human Cancers
Current Cancer Drug Targets Gene Therapy for Pituitary Tumors
Current Gene Therapy Pharmacogenetics of Therapy in Inflammatory Bowel Disease Patients
Current Pharmacogenomics Overlapping Ligand Specificity of P-Glycoprotein and Serum α1-Acid Glycoprotein:Evidences and Potential Implications
Current Drug Metabolism 1,3,5-Triazine Analogs: A Potent Anticancer Scaffold
Current Signal Transduction Therapy Clostridium difficile Infection: Associations with Chemotherapy, Radiation Therapy, and Targeting Therapy Treatments
Current Medicinal Chemistry Current Prodrug Strategies for the Delivery of Nucleotides into Cells
Drug Design Reviews - Online (Discontinued) Mango Polyphenols and Its Protective Effects on Diseases Associated to Oxidative Stress
Current Pharmaceutical Biotechnology The Dual Role of Tumor Necrosis Factor (TNF) in Cancer Biology
Current Medicinal Chemistry Methotrexate: Should We Start Using it in Clinical Practice?
Current Drug Targets Presenilin and γ -Secretase Activity: A Viable Therapeutic Target for Alzheimers Disease?
Current Signal Transduction Therapy Plasminogen Activator System and Vascular Disease
Current Vascular Pharmacology