Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal
chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is
amenable to many structural modifications. These agents have several favorable properties such as excellent
bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects.
They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the
therapeutic potential of imidazoles as antifungal with an updated account on their development.
Keywords: Antifungal agent, Antimycotic agent, Imidazole, Structure-Activity Relationship study.
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Published on: 26 August, 2013
Page: [1626 - 1655]