Imidazoles as Potential Antifungal Agents: A Review

Author(s): Nidhi Rani, Ajay Sharma, Girish Kumar Gupta, Randhir Singh

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 11 , 2013


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Abstract:

Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.

Keywords: Antifungal agent, Antimycotic agent, Imidazole, Structure-Activity Relationship study.

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Article Details

VOLUME: 13
ISSUE: 11
Year: 2013
Published on: 26 August, 2013
Page: [1626 - 1655]
Pages: 30
DOI: 10.2174/13895575113139990069
Price: $65

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