Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

Author(s): Pankaj B. Miniyar, Prashant R. Murumkar, Pallavi S. Patil, Mahesh A. Barmade, Kailash G. Bothara

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 11 , 2013

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Abstract:

Pyrazine is one of the important class of heterocyclic compounds that can be obtained naturally or synthesized chemically. Pyrazine ring has got importance in exhibiting various biological activities in association with other scaffolds like pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, oxazole, pyridine, piperidine and piperazine. Presence of pyrazine ring as a basic scaffold in various clinically used drugs exhibits its importance in drug design. In this review, attempt has been made to disclose various therapeutic applications of pyrazine derivatives reported during the last decade.

Keywords: Pyrazine, anti-tubercular agents, anticancer agents, diuretics, anti-diabetic agents.

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Article Details

VOLUME: 13
ISSUE: 11
Year: 2013
Page: [1607 - 1625]
Pages: 19
DOI: 10.2174/1389557511313110007
Price: $65

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