Pyrazine is one of the important class of heterocyclic compounds that can be obtained naturally or synthesized
chemically. Pyrazine ring has got importance in exhibiting various biological activities in association with other scaffolds
like pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, oxazole, pyridine, piperidine and piperazine. Presence of
pyrazine ring as a basic scaffold in various clinically used drugs exhibits its importance in drug design. In this review,
attempt has been made to disclose various therapeutic applications of pyrazine derivatives reported during the last decade.