This article purposes to provide insights to piperazine based molecular designs that will facilitate drug
discovery program in future. In our pursuit to summarize the reservoir of bioactive agents, and in line with the synthetic
economy of new heterocycles, many new roles are being identified for the multiple biotargets of piperazine moieties. We
mark out how series of different scaffolds provide an extensive range of various piperazine-based analogues displaying
antimicrobial, antituberculosis, anticancer, antiviral and antimalarial activities. We believe that piperazine family of
compounds, and their various co-components, highlight the existence of several potential leads for the furtherance of
novel bioactive agents.