In order to overcome the significant side effects and the acquired resistance of platinum-based anticancer drugs,
great efforts have been devoted to designing new platinum compounds or non-platinum transition metal anticancer complexes
with improved pharmacological properties and a broader range of antitumor activity. Among them, the new complexes
based on natural alkaloid and their derivatives provide a novel approach to potential (pro-)drugs. This review was
mainly focused on the recent progresses of alkaloid-metal based anticancer agents, including metal complexes of natural
or synthetic alkaloids, liriodenine, β-carboline, and quinolinoline as anticancer agents, their in vitro anticancer activities
and primary action mechanism. Additionally, the future development of hybrid alkaloid and its derivatives metal complexes
as anticancer drugs was discussed, which might hold a promise for overcoming multidrug resistance (MDR).
Keywords: Alkaloid, liriodenine, β-carboline alkaloid, quinolinoline, anticancer agents, metal complexes.
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