From the Multifactorial Nature of Alzheimer`s Disease to Multitarget Therapy: The Contribution of the Translational Approach

Author(s): Laura Calzà, Vito Antonio Baldassarro, Alessandro Giuliani, Luca Lorenzini, Mercedes Fernandez, Chiara Mangano, Sandra Sivilia, Marco Alessandri, Marco Gusciglio, Roberta Torricella, Luciana Giardino

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 15 , 2013

Become EABM
Become Reviewer
Call for Editor


The drug discovery for disease-modifying agents in Alzheimer disease (AD) is facing a failure of clinical trials with drugs based on two driving hypotheses, i.e. the cholinergic and amyloidogenic hypotheses. In this article we recapitulate the main aspects of AD pathology, focusing on possible mechanisms for synaptic dysfunction, neurodegeneration and inflammation. We then present the pharmacological and neurobiological profile of a novel compound (CHF5074) showing both anti-inflammatory and gamma-secretase modulatory activities, discussing the possible time-window for effective treatment in an AD transgenic mouse model. Finally, the concept of cognitive reserve is introduced as possible target for preventive therapies.

Keywords: Tg2576, amyloid precursor protein, cognitive reserve, neuroinflammation, translational medicine.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 26 August, 2013
Page: [1843 - 1852]
Pages: 10
DOI: 10.2174/15680266113139990140
Price: $65

Article Metrics

PDF: 35