The Effect of Adult and Pediatric Cardiopulmonary Bypass on Pharmacokinetic and Pharmacodynamic Parameters

Author(s): Annewil van Saet, Saskia N. de Wildt, Catherijne A.J. Knibbe, Ad J.J.C. Bogers, Robert J. Stolker, Dick Tibboel

Journal Name: Current Clinical Pharmacology
Continued as Current Reviews in Clinical and Experimental Pharmacology

Volume 8 , Issue 4 , 2013


Cardiopulmonary bypass (CPB) is known to have important effects on the disposition of drugs, which in turn may have important implications for the efficacy and toxicity of drug therapy. These effects constantly change throughout CPB and some continue to exert influence after the patient has been successfully weaned. In children, developmental and disease specific changes in drug disposition and effect also need to be taken into account when studying the effects of CPB.

This review will provide an extensive overview of the current literature concerning the mechanisms behind the effects CPB has on pharmacokinetic and pharmacodynamic parameters. Also the effects of CPB on individual anesthetic drugs and sedatives, opioids, neuromuscular blocking agents, antibiotics and miscellaneous medications will be reviewed. Special attention will be paid to the pediatric population.

Keywords: Anesthesiology, cardiac surgery, cardiopulmonary bypass, pediatric, pharmacodynamics, pharmacokinetics.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 23 August, 2013
Page: [297 - 318]
Pages: 22
DOI: 10.2174/15748847113089990067
Price: $65

Article Metrics

PDF: 55