The Immunopathology of Tuberculosis – An Update

Author(s): Colin S. Brown, Nicholas M. Price

Journal Name: Current Respiratory Medicine Reviews

Volume 9 , Issue 3 , 2013

Become EABM
Become Reviewer
Call for Editor


Although Mycobacterium tuberculosis infection remains a global killer, many immunopathological aspects of the disease are poorly understood, and defence mechanisms long thought to help host defences such as granuloma formation have recently been challenged. This review highlights contemporary evidence that granulomas may benefit mycobacterial survival and dissemination, particularly citing the zebrafish model of pathogenesis. Other selected examples of novel research covered include the role of the lung extracellular matrix, mycobacterial evasion techniques, chemokine response, immune reconstitution in the context of human immunodeficiency virus, and biomarker development. These advances may yield improved diagnostics and offer targets for anti-tuberculous chemotherapy and vaccine development.

Keywords: Granuloma, immunology, pathology, paradigm, review, tuberculosis, zebrafish.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 31 August, 2013
Page: [151 - 155]
Pages: 5
DOI: 10.2174/1573398X113099990020
Price: $65

Article Metrics

PDF: 10