An Efficient and Environmentally Benign Access Towards Synthesis of Novel 1,2,3-Triazolyl-pyrazoline Hybrids

Author(s): Poovan Shanmugavelan, Sangaraiah Nagarajan, Murugan Sathishkumar, Raja Ranganathan, Alagusundaram Ponnuswamy

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 6 , 2014

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Graphical Abstract:


An efficient and facile synthesis of a library of hitherto novel 1,2,3-triazolyl-pyrazoline hybrids in water medium has been achieved in excellent yields from easily accessible 1,2,3-triazole linked chalcone precursors. Herein, its noteworthy that the yield of 1,2,3-triazolyl-pyrazoline hybrids in water medium is as good as in commonly used organic solvent for pyrazoline synthesis viz. ethanol. Present protocol involving mild reaction condition, excellent yield and simple reaction procedure was found to be the best synthetic strategy for 1,2,3-triazolyl-pyrazoline hybrids in view of environmentally benign consciousness.

Keywords: Efficient, environmentally benign, 1, 2, 3-triazolyl chalcones, 1, 2, 3-triazolyl pyrazoline hybrids, water mediated.

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Article Details

Year: 2014
Page: [446 - 456]
Pages: 11
DOI: 10.2174/15701786113109990050
Price: $65

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