T3 and Cardiac Myocyte Cell: A Theoretical Model

Author(s): Tsatsaris Athanasios, Baldoukas Antonios, Loumousiotis Antonios, Koukounaris Eustathios, Giota Maria, Perrea Despina

Journal Name: Recent Patents on Cardiovascular Drug Discovery
Continued as Recent Advances in Cardiovascular Drug Discovery

Volume 8 , Issue 2 , 2013


In the last decades, the outstanding role of Thyroid gland in regulating both physiological and pathological operation of cardiovascular system has been acknowledged worldwide. Three main domains of Thyroid function, that is to say, euthyroidism -hyperthyroidism-hypothyroidism, have a direct impact on cardiac response through a variety of mechanisms. Cellular pathways mediate in cardiac contractility, cardiac output, cardiac rhythm, arterial blood pressure and peripheral vessel resistance. Particular biochemical algorithms exist not only between Thyroid hormones’ serum concentration and thyroid gland but also between the hormones’ serum level and heart muscle genes. These biochemical pathways primarily regulate the appropriate secretion of levothyroxine (T4) and triiodothyronine(T3) via Thyroid- Stimulating-Hormone(TSH) pituitary system, and secondly adjust the cardiac function. In this study, a mathematic model has been developed describing significant aspects of positive or negative feedback mechanisms of THYRO-CARDIAC (THY-CAR) system along with potential applications of novel up-to-date patents in this area of research.

Keywords: Cardiovascular disease, cellular mechanism, mathematic model, thyroid hormone, thiidothyronine.

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Article Details

Year: 2013
Published on: 31 July, 2013
Page: [162 - 165]
Pages: 4
DOI: 10.2174/15748901113089990022
Price: $65

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