A new combination of reagent (ZnCl2/TBAB) system has been developed for the preparation of dihydropyrimidinones
by using aldehyde, acetoacetic ester and urea or thiourea. These improved reaction condition allow the
preparation of a wide variety of substituted dihydropyrimidinones in high yields and purity under mild reaction conditions.
Some of the dihydropyrimidinones were showed moderate in vitro cytotoxic activity against U937, Colo205, A549
and THP-1 human cancer cell lines. Some of the compounds have been found promising anticancer activity when compared
standard drug etoposide.
Keywords: Biginelli reaction, ZnCl2/TBAB catalyst, Dihydropyrimidinones, One pot synthesis, MTT assay, Cytotoxicity.
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