Title:Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents
VOLUME: 10 ISSUE: 8
Author(s):Wenli Lan, Jingchen Wei, Jiangke Qin, Zhengmin Yang, Guifa Su and Zhikai Dai
Affiliation:College of chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, P.R. China.
Keywords:Xanthone derivatives, Synthesis, Mannich bases, Antitumor activity, Structure-activity relationships, MTT assay.
Abstract:A novel series of Mannich bases of 1, 3-dihydroxyxanthone derivatives were designed and synthesized. The
chemical structures of the compounds were characterized by IR, MS and NMR spectra. Their in vitro toxicities on six tumor
cell lines including NCI-H460 (lung cancer), TCA-8113 (tongue squamous cell carcinomas), BEL-7402 (liver cancer),
HepG2 (hepatocarcinoma), SGC-7901 (gastric carcinoma) and T24 (urinary bladder carcinoma) were studied
through MTT assay. The results showed that most of the compounds displayed mild to good inhibitory activities on the
cancer cell lines. Some preliminary structure-activity relationships were also discussed.
