Characterizing the Functional Similarity of Enzymes with High Co-Citation in Interaction Networks

Author(s): Lilla Tothmeresz, Vince Grolmusz

Journal Name: Protein & Peptide Letters

Volume 20 , Issue 10 , 2013

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New methods for reliable quantitative analysis of biological network data are in high demand in today’s bioinformatics and systems biology. Here we demonstrate the applicability of the co-citation, developed earlier for the analysis of scientific literature for finding functionally similar nodes in protein-protein interaction networks in several model organisms. We prove the power of our approach in a novel way: the predicted closely related enzymes are compared to the closeness of their enzyme commission (EC) numbers, therefore we can numerically evaluate our prediction method. We have found clear correspondence between related enzymatic functions and high co-citation of proteins in interaction networks.

Keywords: Co-citation, protein interaction networks, vertex similarity.

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Article Details

Year: 2013
Published on: 31 July, 2013
Page: [1181 - 1187]
Pages: 7
DOI: 10.2174/0929866511320100013
Price: $65

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