Title:MicroRNAs and Cancer Therapy – From Bystanders to Major Players
VOLUME: 20 ISSUE: 29
Author(s):Cornelia Braicu, George A. Calin and Ioana Berindan-Neagoe
Affiliation:Departments of Experimental Therapeutics and Leukemia, The Leukemia, The University of Texas MD Anderson Cancer Center, South Campus Research Bldg. 3 (3SCR4.3424) 1881 East Road, Unit 1950, Houston, TX 77030.
Keywords:Cancer, microRNA, miRNA cascade, miRNA- based therapy.
Abstract:MicroRNAs (miRNAs) are an evolutionarily conserved class of small regulatory RNAs that modulate gene expression.
Extensive research over the last decade has shown that miRNAs are master regulators of cellular processes, with
an essential role in cancer initiation, progression, and metastasis. Widespread deregulation of miRNAs in cancers has
identified oncogenic and tumor-suppressive roles for these miRNAs. On the basis of these observations, miRNAs have
emerged as promising therapeutic tools for cancer management. In this review, we focus on the roles of miRNAs in tumorigenesis,
the rationale and strategies for the use of miRNA-based therapy for cancer, and the advantages and current
challenges to their use.
