The case of an HIV-positive treatment-naive male with toxic shock syndrome (TSS) is presented herein. The
course of TSS was favorable; however, the patient had extremely high plasma levels of MCP-1 and CD38 and HLA-DR
expression on CD8+ T cells during the acute illness. Furthermore, the numbers of CD8+ T cells were reduced and CD4+
T cells remained stable during acute illness in comparison to baseline values. MCP-1 and HLA-DR gradually decreased,
but they were still elevated after a month, whereas the number of circulating CD8+ T cells increased more than fivefold.
CD38 expression remained stable during this period. A further decrease in CD38, HLA-DR and MCP-1 was noted five
months after the initiation of antiretroviral therapy.
Keywords: Combined antiretroviral therapy, CD38, HIV infection, HLA-DR, MCP-1, toxic shock syndrome.
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Published on: 22 September, 2013
Page: [321 - 325]