Pyrazole Derivatives as Antitumor, Anti-Inflammatory and Antibacterial Agents

Author(s): Jia-Jia Liu, Meng-yue Zhao, Xin Zhang, Xin Zhao, Hai-Liang Zhu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 13 , 2013

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Abstract:

Within the past years, many researches on the synthesis, structure-activity relationships (SAR), antitumor, antiinflammatory and anti-bacterial activities of the pyrazole derivatives have been reported. Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAFV600E, EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities. In this review, the bioactivities of the pyrazole derivatives mentioned above will be summarized in detail. We sincerely hope that increasing knowledge of the SAR and cellular processes underlying the bioactivity of pyrazole derivatives will be beneficial to the rational design of new generation of small molecule drugs.

Keywords: Pyrazole derivatives, bioactivity, drug targets.

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2013
Page: [1957 - 1966]
Pages: 10
DOI: 10.2174/13895575113139990078
Price: $65

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