Within the past years, many researches on the synthesis, structure-activity relationships (SAR), antitumor, antiinflammatory
and anti-bacterial activities of the pyrazole derivatives have been reported. Several pyrazole derivatives
possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole
derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAFV600E, EGFR,
telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory
and anti-bacterial activities. In this review, the bioactivities of the pyrazole derivatives mentioned above
will be summarized in detail. We sincerely hope that increasing knowledge of the SAR and cellular processes underlying
the bioactivity of pyrazole derivatives will be beneficial to the rational design of new generation of small molecule drugs.