Inflammasome and Atherogenesis

Author(s): Xinjie Lu, Vijay Kakkar

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 1 , 2014

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Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. Inflammation and the innate immune response are involved in the formation of early atherosclerotic lesion. A protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are responsible for activation of inflammatory processes. Inflammasome-mediated processes are important in the process of atherosclerosis. The front of structure domains as well as IL-1, and IL-18 stands at the threshold of the adaptive immune response that accelerates full-blown atherosclerotic disease progression. This review is intended to provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for therapy of this disease.

Keywords: Inflammasome, atherosclerosis, atherosgenesis, autophagy, caspase.

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Article Details

Year: 2014
Published on: 13 January, 2014
Page: [108 - 124]
Pages: 17
DOI: 10.2174/13816128113199990586
Price: $65

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