Objective: The aim of this study was to analyze the relationship between
Alzheimer’s disease (AD) and a risk of osteoporosis in the elderly cohort of
Methods: A prospective study with 6 years of follow-up in 1802 patients aged 60–
75 was conducted from January 2007 to June 2013. Dual energy X-ray absorptiometry
was utilized to evaluate bone mineral density (BMD). Their cognitive function
was detected using the Chinese version of the Mini-Mental State Examination
(MMSE) and a detection of the instrumental activities of daily living (ADL). Cox
proportional hazards models were used to detect the association between AD and
the risk of osteoporosis.
Results: After adjusting for age, female, AD, 25-hydroxyvitamine D (25(OH)D), smoking, drinking
and stroke, AD (Hazard ratio, HR 2.48, 95%CI 1.66-2.94), age (HR 1.36, 95% CI 1.14-1.60), female
(HR 1.39, 95% CI 1.17-1.65), 25(OH)D (HR1.34, 95%CI 1.11-1.59), current smoking (HR 1.27,
95%CI 1.22-1.43), daily drinking (HR 1.33, 95%CI 1.11-1.52) and stroke (HR 1.26, 95%CI 1.14-1.58)
were associated with increased risk of osteoporosis. In osteoporosis fracture group, osteoporosis with
AD was more common than osteoporosis with normal cognition function.
Conclusion: AD was associated with an increased risk of osteoporosis in the elderly cohort of