Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines

Title:Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines

Volume: 11 Issue: 1

Author(s): Ban-Feng Ruan, Si-Qi Wang, Xiao-Lin Ge and Ri-Sheng Yao

Affiliation:

Keywords: Resveratrol, Acrylamides amine, Anti-proliferative effect, SynthesisResveratrol, Acrylamides amine, Anti-proliferative effect, Synthesis

Abstract: A new series of resveratrol acrylamides amine derivatives was designed, synthesized, and evaluated for their anti-proliferative activity against three cancer cell lines including human chronic myelocytic leukemia cell K562, human hepatoma HuH-7 and human lung carcinoma A549. Most of the compounds showed superior activity against three cell lines when compared to parent resveratrol. C13 had the best anti-tumor activity against the HuH-7 cell line and its IC50 was 4.5 μmol/L; C16 had the best anti-tumor activity against the K562 cell line and its IC₅₀ was 2.9 μmol/L; C18 had the best anti-tumor activity against the A549 cell line and its IC₅₀ was 3.8 μmol/L. It could be seen that the activity of the aromatic amine derivatives was better than the fatty amine derivatives by analyzing the experimental data.

Cite this article as:

Ruan Ban-Feng, Wang Si-Qi, Ge Xiao-Lin and Yao Ri-Sheng, Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines, Letters in Drug Design & Discovery 2014; 11 (1) . https://dx.doi.org/10.2174/15701808113109990057