A Genopedia of Lupus Genes - Lessons from Gene Knockouts

Author(s): Yuyuan Guo, Jacob Orme, Chandra Mohan

Journal Name: Current Rheumatology Reviews

Volume 9 , Issue 2 , 2013

Become EABM
Become Reviewer


Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at http://www.mohanlab.org/SLE_BASE/gene.

Keywords: Systemic Lupus Erythematosus, genetic susceptibility, mouse models.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Page: [90 - 99]
Pages: 10
DOI: 10.2174/1573397111309020003
Price: $65

Article Metrics

PDF: 12